- #Pre post correlation comprehensive meta analysis manual
- #Pre post correlation comprehensive meta analysis trial
And, yes, I would think that one should account for non-independent outcomes (e.g.
R (many packages such as metafor, brms etc. In principle, the calculations you would want to do, if change from baseline were a meaningful thing to meta-analyze would be quite straightforward to implement using e.g. To summarize: unless you have a massive effect that you are studying, it is typically very, very hard to reliably conclude whether an intervention compared to historical controls does something. inclusion criteria) and there is quite a literature on such indirect comparisons. The only cases where it makes some sense, is if you informally or formally compare to some known natural history for patients that have been selected in a similar manner (incl. Particularly, if you have an inclusion criterion for a study or analysis that requires a certain pre-treatment level, then you are more or less guaranteed an improvement (very often by substantial amounts) simply by regression to the mean (never mind the Hawthorne effect). They are not a useful thing to meta-analyze, if you wish to say something on the efficacy or effectiveness of therapies.
There is a reason why there is less information on the meta-analysis of within-group changes. Are there any other good programs that are cheap/free that would do what I want? I have also looked into RevMan, but from what I can gather it only supports inter-group comparisons, since Cochrane reviews are typically looking at mean differences comparing a treatment against control/placebo/gold standard.
#Pre post correlation comprehensive meta analysis trial
Presumably I could use R since there are so many packages available – any suggestions on packages that might suit? Based on a trial of the program Comprehensive Meta-Analysis it seems to do what I’m looking for, but is rather expensive ($500 for 1 year license, unless I purchase with my own money as a student). If I can, I’m uncertain of which programs would allow me to do it. Most information out there about meta-analysis is very focused on inter-group comparisons so I've been unable to find a clear answer. Can I do this? And if so, how do I go about it? I’ll need to run it under a random-effects model. at the lower back and at the calf) so each site needs to be included separately. There are 10 studies, and most studies have multiple testing sites (e.g. I will be using mean change from baseline (continuous) and I have SDs/CIs of the change. within-group change), so there is no comparison to sham/control.
#Pre post correlation comprehensive meta analysis manual
I am trying to run a meta-analysis calculating the mean effect size of a manual therapy treatment on pressure pain threshold pre-post treatment (i.e.